The ingredient Cissus Quadrangularis in CissusMax™ have been used safely in India for centuries. Some of the amazing properties of Cissus Quadrangularis are actual re-growth of tendons, ligaments and bone! That’s right – re-growth. CissusMax™ is so unique and powerful; it can even help repair old, nagging injuries that have bothered you for years. It’s like having a coat of armour protecting your body at all times!

In addition, CissusMax™can significantly lower cortisol, which can lead to increased Testosterone levels and new muscle tissue. Cissus Quadrangularis has also proven to be a potent anabolic/anti-catabolic agent without suppressing natural hormonal levels!

In fact, a recent clinical study proved Cissus Quadrangularis to be a stronger anti-catabolic than Deca & Dbol! Now that doesn’t necessarily mean you will gain 30 pounds of muscle overnight, but it does mean CissusMax™will significantly help rebuild and repair your joints, tendons, ligaments, keep you in a positive nitrogen balance and slash your recovery time from workouts.

The great thing is it’s 100% safe! No signs of toxicity, even at mega doses.

Don’t Let Injuries Stop You From Gaining Enormous Amounts Of Muscle And Getting Ripped To The Bone

Most if not all athletic or bodybuilding careers end because of tendon, ligament and cartilage injuries. Many intelligent athletes are using CissusMax™ as a preventative aid to fight off these injuries. CissusMax™ is the only known legal compound that builds tendon and ligament strength.

It has been my experience that many bodybuilders and athletes take anti-inflammatory medications to fight through the pain. Ultimately, these medications only kill the sensation of pain not the symptom. CissusMax™ has demonstrated the ability to kill the pain specific to the injury, while promoting tissue regeneration.

In addition, these anti-inflammatory medications stop protein synthesis in its tracks. If you aren’t aware, one of the biggest reasons why anabolic Steroids work so well is because they dramatically increase protein synthesis. So each time you take ibuprofen or any other NSAIDS, you are preventing your body from building muscle! Do yourself a favor and stop taking them.

CissusMax™ actually increases protein synthesis. So while your body rebuilds and regenerates connective tissue, you can build muscle too!

Here are just some of the great benefits you can get by using CissusMax™…

• Safely & Effectively Rebuilds Tendons & Ligaments – Only natural herb in the world proven to do so.
• Scientifically proven more powerful anti-catabolic properties than Deca & D-Bol – Preserve muscle mass better than any natural substance!
• Keeps body in positive nitrogen balance 24/7!
• Significantly lowers cortisol by at least 31 %!
• Powerful pain reliever – without damaging effects that ibuprofen brings.
• 100% Safe & effective – Has been used for centuries in India.
• So powerful it’s Patent Pending!

Here’s the scientific write-up…

Cissus Quadrangularis is an ancient medicinal plant native to the hotter parts of Ceylon and India. Cissus Quadrangularis was prescribed in the ancient Ayurvedic texts as a general tonic and analgesic, with specific bone fracture healing properties. Modern research has shed light on Cissus’ ability to speed bone healing by showing it acts as a glucocorticoid antagonist (1,2).

Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing, it has been postulated that Cissus Quadrangularis possesses anabolic and/or androgenic properties (1,3). In addition to speeding the remodeling process of the healing bone, Cissus Quadrangularis also leads to a much faster increase in bone tensile strength.

In clinical trials Cissus Quadrangularis has led to a fracture healing time on the order of 55 to 33 percent of that of controls. That cissus exerts antiglucocorticoid properties is suggested by a number of studies where bones were weakened by treatment with cortisol, and upon administration of Cissus Quadrangularis extract the cortisol induced weakening was halted, and the healing process begun.

While the increased rate of bone healing may be of great significance to persons suffering from chronic diseases like osteoporosis (4), the antiglucocorticoid properties of Cissus Quadrangularis are likely of much more interest to the average bodybuilder or athlete, since endogenous glucocorticoids, particularly cortisol, are not only catabolic to bone, but catabolize muscle tissue as well.

Numerous studies over the years have suggested that glucorticoids, including the body’s endogenous hormone cortisol activate pathways that degrade not only bone, but skeletal muscle tissue as well. A recently published report documented exactly how glucocorticoids (including cortisol) induce muscle breakdown: They activate the so-called ubiquitin-proteasome pathway of proteolysis (5). This pathway of tissue breakdown is important for removing damaged and non-functional proteins.

However, when it is overactive during periods of elevated cortisol (e.g disease states, stress, and over-training) excess amounts of normal tissue are broken down as well. By exerting an anabolic, antiglucorticoid effect Cissus Quadrangularis helps preserve muscle tissue during times of physical and emotional stress.

Although the bulk of the research on Cissus Quadrangularis centers around bone healing, the possibility exists that Cissus may act to improve bone healing it may improve the healing rate of connective tissue in general, including tendons. If this is the case it would be of great benefit to bodybuilders and athletes.

Besides the above-mentioned properties of Cissus Quadrangularis, the plant is also rich in the vitamins/antioxidants vitamin C and beta-carotene. As analyzed, Cissus quadrangularis contained ascorbic acid 479 mg, and carotene 267 units per 100g of freshly prepared paste in addition to calcium oxalate (6).

The typical recommended daily dosage of Cissus Quadrangularis is 1-2 grams to accelerate fracture healing. Safety studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So not only is Cissus efficacious, it is also quite safe, in either the dried powder form or the commercially available extract.

Cissus Quadrangularis also possess analgesic properties on a mg per mg basis comparable to aspirin or anti-inflammatory drugs like ibuprofen. Cissus quadrangularis, which has been proved to be highly effective in relieving pain, reduction of swelling and promoting the process of healing of the simple fractures as well as in curing the allied disorders associated with fractures (7). The mechanism through which Cissus Quadrangularis exerts its analgesic and anti-inflammatory properties has not been well characterized. It may act centrally, but the anti-inflammatory features suggest that it acts by preventing the conversion of arachidonic acid to inflammatory prostaglandins. Real World Application for injuries.

Simply if you’re suffering from joint pain, ligament pain, cartilage pain, had surgery on bone, ligament or cartilage, Cissus is the supplement to use. It has been my experience that many athletes take anti-inflammatory medications to fight through the pain. Ultimately, these medications only kill the sensation of pain not the symptom. Cissus has the ability to kill the pain specific to the injury while promoting healing.

Some users will get instant relief and other will need to use Cissus for much longer period of time for complete healing of an injury. Leverage performance science is not claiming that Cissus will work 100% percent of the time that would be a foolish claim. We have estimated that 85% of user experience relief from our product. This number may lower or rise as more consumers send in reports. In the PHARMACEUTICAL industry a 50% success rate is good. Since we’re talking about the Pharmaceutical industry, they have yet to produce a product that helps the healing process. They just develop pain medications that are often addicting.

CissusMax is anabolic and anti-catabolic!!! CissusMax users report a "PUMP" that we call the CissusMax pump. The PUMP effect becomes prevalent at approximately 10-15 days of continuous CissusMax use. The "PUMP" is due to the increase of blood flow to the muscle. The CissusMax pump will have you flexing your muscle for no apparent reason. This is when you know the product has exerted its effect.

If using CissusMax to heal injury related pain, you may experience instant relief due to its analgesic (pain killing) effect . This does not mean the injury has completely healed! Please continue your training regimen with extra caution until full recovery has been achieved. On the contrary, if using CissusMax primarily for its anabolic properties your training program should be continued with maximum intensity to reap the full benefits of this product.

Cissus quadrangularis showed a marked influence in the rate of fracture- healing by influencing early regeneration of all connective tissues of mesenchyma origin, namely the fibroblasts, the chondroblasts and osteoblasts involved in the healing and quicker mineralization of the callus. It has greater impact on osteoblastic proliferation than other cellular responses.
Cissus quadrangularis causes less amount of tissue reaction in the fractured region leading to optimum decalcification in the early stage with minimum of callus formation. Hence deposition of calcium is just enough to join the two broken segments of bone so that it’s remodeling takes much faster. This early completion of calcification process and earlier remodeling phenomenon lead to early recovery of Cissus treated animals. Cissus is also shown to cause early gain in the tensile strength of fractured bones of about 90 per cent of its normal strength at the end of 6 week. Cissus quadrangularis builds up the chemical composition of the fractured bone namely its mucopolysaccharides, collagen, calcium, phosphorus and others as well as its functional efficiency. Mucopolysaccharides play an important role in the healing by supplying raw materials for repairs. Therefore it seems that in the early period of bone fracture healing the greater the accumulation of these materials more rapid will be the rate of healing. Rapid the utilization of these raw materials earlier will be completion of healing process. Cissus quadrangualris not only causes the greater accumulation of mucopolysaccharides but also an earlier disappearance of mucopolysaccharides from the fractured area, associated with the earlier calcification and firmer callus formation.
In clinical trials Cissus quadrangularis as per radiological and clinical observations has been found to cause considerable reduction in the healing time of fractures by 55-33 percent. In few of the treated cases, although radiologically only, an early callus formation was observed but clinically the symptoms of fracture such as pain, tenderness, and swelling were significantly absent.

The typical recommended daily dosage of Cissus extract is between 1000 and 1500 mg, depending on the concentration of the extract and the severity of symptoms. For the powder of the dried plant.

Cissus quadrangularis showed a marked influence in the rate of fracture- healing by influencing early regeneration of all connective tissues of mesenchyma origin, namely the fibroblasts, the chondroblasts and osteoblasts involved in the healing and quicker mineralization of the callus. It has greater impact on osteoblastic proliferation than other cellular responses.
Cissus quadrangularis causes less amount of tissue reaction in the fractured region leading to optimum decalcification in the early stage with minimum of callus formation. Hence deposition of calcium is just enough to join the two broken segments of bone so that it’s remodeling takes much faster. This early completion of calcification process and earlier remodeling phenomenon lead to early recovery of Cissus treated animals. Cissus is also shown to cause early gain in the tensile strength of fractured bones of about 90 per cent of its normal strength at the end of 6 week. Cissus quadrangularis builds up the chemical composition of the fractured bone namely its mucopolysaccharides, collagen, calcium, phosphorus and others as well as its functional efficiency. Mucopolysaccharides play an important role in the healing by supplying raw materials for repairs. Therefore it seems that in the early period of bone fracture healing the greater the accumulation of these materials more rapid will be the rate of healing. Rapid the utilization of these raw materials earlier will be completion of healing process. Cissus quadrangualris not only causes the greater accumulation of mucopolysaccharides but also an earlier disappearance of mucopolysaccharides from the fractured area, associated with the earlier calcification and firmer callus formation.
In clinical trials Cissus quadrangularis as per radiological and clinical observations has been found to cause considerable reduction in the healing time of fractures by 55-33 percent. In few of the treated cases, although radiologically only, an early callus formation was observed but clinically the symptoms of fracture such as pain, tenderness, and swelling were significantly absent.

Did you ever wonder why some guys build muscle and it just stays on them and continues to grow, while others grow thin and week after missing the gym for a week? The answer lies in your bodies production of  two hormones called DHEA and Cortisol. When you are working out, healthy and generally feel good, your body produces DHEA, which builds muscle and regenerates the body.  But, when you are immobile and have stress your body produces Cortisol which breaks down muscle.

The bottom line is, if you’re among the band of hard-and-heavy lifters, cortisol may be literally eating away at your muscle-building potential. Weight training enthusiasts must declare all-out war on this catabolic hormone if they have any aspirations of building muscle.

Cortisol reduces the utilization of amino acids for protein formation in muscle cells. A cortisol excess can lead to a progressive loss of protein, muscle weakness and atrophy, and loss of bone mass through increased calcium excretion and less calcium absorption. That is one of the reasons long-distance runners tend to have skinny physiques. With the amount of stress that runners place on their bodies, they have high levels of free radicals as well as cortisol. Excess cortisol can also adversely affect tendon health. Cortisol causes a redistribution of bodyfat to occur through an unknown mechanism. Basically, the extremities lose fat and muscle while the trunk and face become fatter. Some of the signs of overtraining include higher cortisol levels, which may cause depression-type effects. Cortisol excess can also lead to hypertension because it causes sodium retention (which can make you appear bloated) and potassium excretion. In other words, excessively high cortisol levels may make you thin and chubby. So the real challenge becomes how to control cortisol levels.

So, it becomes odvious to anyone who wants to build muscle that they must learn to reduce cortisol levels. In the past pro bodybuilders would take expensive injections in order to block there cortisol receptors. With the intensive research in biopharmacology a solution was found in a natural herbal extract called,“ Cissus Quadrangularis”. Cissus was proven in laboratories to reduce cortisol levels.

One of the reason bodybuilders where not taking this essential supplement before was because this rare herb only grows in remote locations in South East Asia. Since the discovery of cissus quandrangularilus it has become the solution to the war on cortisol.

The way to take the anti-cortisol supplement CissusMax is in the morning and before bedtime, as these are two times that cortisol levels seem to be raised. The key is to suppress elevated levels of cortisol with a synergistic herbal supplement like CissusMax that will let your body recover and grow.  Cissus Quadrangularis is packed with nutrients, antioxidants and high levels of Kertonoids, with no known side effects.

Cortisol suppression with CissusMax is an essential part in the growth and protection of muscle fibers and tendons. With the simple addition of Cissus Max you will become one of those guys who easily gains muscle and just keeps it on. Increase you potential with CissusMax or wither away.

 

Cissus Quadrangularis health benefit by Ray Sahelian, M.D.

Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoids. For a free newsletter, click the image below which takes you to Physician Formulas web site, and then enter your email address in the box provided. Cissus quadrangularis has a number of substances including iridoids such as picroside, stilbenes quadrangularin A, pallidol, quercitin, quercitrin, beta-sitosterol, and beta-sitosterol glycoside. See a list of botanical names.

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Cissus quadrangularis and hemorrhoid pain
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.
J Ethnopharmacol. 2006 Sep 26; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of Cassius quadrangularis were assessed in comparison with reference drugs. In the analgesic test, Cissius quadrangularis provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. Cissius quadrangularis also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of Cissius quadrangularis. In acute phase of inflammation Cassius quadrangularis elicited the inhibitory effect on the edema formation of the rats’ ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that Cissius quadrangularis is a dual inhibitor of arachidonic acid metabolism. In addition, Cissius quadrangularis exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of cissius quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.

Cissus quadrangularis and weight loss
The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.
Lipids Health Dis. 2007 Feb 4;6:4. Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA. Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon.
The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people. The first part of the study investigated the in vitro antioxidant properties of Cissus quadrangularis and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons. All participants received two daily doses of Cissus quadrangularis, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Cissus quadrangularis (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

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The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.
Lipids Health Dis. 2006 Sep 2;5:24. Department of Biochemistry, University of Yaounde I, Yaounde, Cameroon.
The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity. The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100-2200 calories/day). The 31 overweight participants (BMI = 25-29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks. At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet. Cissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.

Cissus quadrangularis and ulcer
Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage.
Chem Biol Interact. 2006 Jul 10;161(3):262-70. Epub 2006 May 1. Department of Biochemistry, University of Madras, A.C. Tech, Guindy Campus, Chennai 600025, Tamil Nadu, India.
The objective of this research was to analyse the gastroprotective effect of Cissus quadrangularis extract along with its mechanism underlying the therapeutic action against the gastric mucosal damage induced by aspirin. In this study, we investigated the effect of Cissus quadrangularis extract on the course of experimentally induced gastric ulcer by analyzing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), microvascular permeability, activity of nitric oxide synthase-2 (NOS-2), mitochondrial antioxidants, lipid peroxidation and DNA damage. A significant increase in vascular permeability, NOS-2 activity, TNF-alpha, IL-1beta levels and oxidative damage were noted in aspirin administered rats. Pretreatment with Cissus quadrangularis extract (500 mg/kg bw/day) by oral gavage for 7 days significantly attenuated these biochemical changes caused by aspirin in rats. Tissue damage was showed by decreased levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) and an associated rise in lipid peroxidation (LPO) in mitochondria, which were reversed by Cissus quadrangularis extract . In addition, Cissus quadrangularis extract prevents oxidative damage of DNA by reducing DNA fragmentation indicating its block on cell death. Ulcer protection in Cissus quadrangularis extract treated rats was confirmed by histoarchitecture, which was comprised of reduced size of ulcer crater and restoration of mucosal epithelium. Thus, reduced neutrophil infiltration, antiapoptotic and antioxidant action have a pivotal role in the gastroprotective effect of Cissus quadrangularis extract.

Cissus quadrangularis extract availability from raw herb and ingredient suppliers
Cissus quadrangularis extract comes in various potencies including 4% ketosteroids, 5% ketosteroids, a 5 to 1 extract and a 20 to 1 extract. 

Cissus quadrangularis herb emails
Q. What can you tell me about Cissus (or veld grape herb)? I read* recently that it “significantly reduces body fat, especially around the waist” and has “anabolic properties” which is wonderful if it’s true. I’m guessing that it’s similar to L-Carnitine in the sense that it’s more effective in obese individuals rather than those who are fit.
   A. I don’t have any personal experience with cissus quadrangularis.

Q. I tried Cylaris to boost weight loss (have lost 35lbs so far without it, but figured it couldn’t hurt). I read the ingredient list and took the recommended half dose. By the third pill I was violently ill with the worst headache I had ever experienced, photophobia, and nausea that progressed to vomiting. It turns out that I am allergic to Cissus Quadrangularis. After doing some research it makes sense, as I have “oral allergy syndrome”, or allergies to most trees / bushes and the proteins that are grown on them (for instance, the only raw vegetables or fruits that I can have are lettuce, cucumber, tomato, onion, and bananas. So much for big salads!). I am not advocating a warning label on any of the supplements, as it is up to the consumer to be aware of their own limitations, but if you ever encounter anyone with these types of allergies, please pass the information along.
   A. Cylaris is a combination of several vitamins, minerals, and natural herbs. According to one website, Cylaris Proprietary Weight Loss Blend has Caffeine Anhydrous, Cissus Quadrangularis Extract, Green Tea Extract, and Soy Albumin Extract. Whenever there is a formula with multiple substances in it, it is difficult to blame any particular ingredient unless each one is tried separately.

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Q. I just wanted to ask if cissus quadrangularis has any blood clotting or blood thinning characteristics? This is if it is taken in a weight loss formula according to directions on the product label. I do not know the rest of the ingredients, but this is the main ingredient and I wanted to find out if it clots or thins a persons blood in any way, since the manufacturers never usually tell a person if it will or not on the supplement fact panel label.
   A. I have not seen human studies with this herb that has looked specifically at its blood clotting or thinning effects but since it contains flavonoids, it is more likely than not to have some blood thinning potential but I can’t be sure.